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Leonie La Blanche Cis'k. Favipiravir is known to have non-linear pharmacokinetics due to its inhibitory effect on its main metabolic enzyme, aldehyde oxidase [ 5 , 6 ], which is also known to have several genetic polymorphisms with different catalytic activities [ 18 ]. Received Sep 26; Accepted Feb 6. S2 Text: Impact of inactivation procedure on plasma favipiravir concentration.

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Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

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In conclusion, we have demonstrated that favipiravir plasma concentrations decreased with time and were likely too low in most patients. Alima Toure. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Ozil Kourouma.
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Contact information for Bongo Africa Market. Valery Kassy. S2 Text Impact of inactivation procedure on plasma favipiravir concentration.
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The closing of HC3 Ebola recovery efforts in Sierra Leone earlier this year was marked by a ceremony held in late March. Kaba Manan. Thus the patients analysed here are not representative of the JIKI population study and this is why they differed in terms of mortality, initial Ct, viral load or biochemical parameters Table 1.
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